Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 11/20 | 0.47 |
| ▸ | PARP11 | Q9NR21 | 8/20 | 0.47 |
| ▸ | PARP1 | P09874 | 8/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29750194 | 0.82 | PARP11 (0.59) | PARP10PARP11PARP1PDPK1MAPK1 | |
| SCHEMBL29964432 | 0.81 | PARP10 (0.44) | PARP10PARP11PARP1PDPK1MAPK1 | |
| SCHEMBL29914493 | 0.81 | PARP10 (0.48) | PARP10PARP11PARP1PDPK1MAPK1 | |
| SCHEMBL24681233 | 0.81 | PARP10 (0.48) | PARP10PARP11PARP1PDPK1MAPK1 | |
| SCHEMBL12495886 | 0.78 | PARP10 (0.48) | PARP10PARP11PARP1MAPK1GRM5 | |
| SCHEMBL18937006 | 0.76 | MAP4K4 (0.50) | PARP10PARP11MAPK1GRM5 | |
| SCHEMBL29963884 | 0.76 | PARP10 (0.42) | PARP10PARP11PARP1MAPK1GRM5 | |
| SCHEMBL12077063 | 0.75 | PARP10 (0.41) | PARP10PARP11PARP1PDPK1MAPK1 | |
| SCHEMBL24680918 | 0.72 | FYN (0.57) | PARP1MAPK1 | |
| SCHEMBL12496236 | 0.71 | GABRG2 (0.47) | PARP10PARP11PARP1MAPK1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |