Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | BMPR1B | O00238 | 4/20 | 0.43 |
| ▸ | BMPR1A | P36894 | 4/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.43 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13201887 | 0.92 | KCNH2 (0.49) | KCNH2DRD3DRD2 | |
| SCHEMBL8247741 | 0.92 | KCNH2 (0.49) | KCNH2DRD3DRD2 | |
| SCHEMBL4629032 | 0.92 | KCNH2 (0.49) | KCNH2DRD3DRD2 | |
| SCHEMBL3769912 | 0.83 | KCNH2 (0.52) | KCNH2DRD3DRD2 | |
| SCHEMBL11915231 | 0.83 | KCNH2 (0.52) | KCNH2DRD3DRD2 | |
| SCHEMBL3397256 | 0.83 | KCNH2 (0.52) | KCNH2DRD3DRD2 | |
| SCHEMBL13823162 | 0.83 | KCNH2 (0.49) | KCNH2DRD3DRD2 | |
| SCHEMBL11911756 | 0.83 | KCNH2 (0.52) | KCNH2DRD3DRD2 | |
| SCHEMBL12313185 | 0.83 | KCNH2 (0.52) | KCNH2DRD3DRD2 | |
| SCHEMBL3769913 | 0.83 | KCNH2 (0.52) | KCNH2DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117597340-A | Substituted amino-aza-heteroaryl compounds as inhibitors of hematopoietic progenitor kinase 1 (HPK 1) | 安大略省癌症研究所(OICR) | 2024-02-23 | — | — | CN | disclosed |
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |
| WO-2022226666-A1 | SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |