Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27159890 | 1.00 | BACE1 (0.37) | BACE1MEN1KMT2ACNR1KCNH2 | |
| SCHEMBL29914800 | 0.91 | BACE1 (0.36) | BACE1ROCK1HIF1A | |
| SCHEMBL27159633 | 0.91 | BACE1 (0.36) | BACE1ROCK1HIF1A | |
| SCHEMBL27159919 | 0.88 | LPL (0.33) | MEN1KMT2ACNR1KCNH2ROCK1 | |
| SCHEMBL29914872 | 0.88 | LPL (0.33) | MEN1KMT2ACNR1KCNH2ROCK1 | |
| SCHEMBL27159650 | 0.88 | LPL (0.33) | MEN1KMT2ACNR1KCNH2KDM4E | |
| SCHEMBL29914723 | 0.88 | LPL (0.33) | MEN1KMT2ACNR1KCNH2KDM4E | |
| SCHEMBL27159901 | 0.84 | BACE1 (0.39) | BACE1ALDH1A1TNFLTA4HKDM4E | |
| SCHEMBL29914919 | 0.84 | BACE1 (0.39) | BACE1ALDH1A1TNFLTA4HKDM4E | |
| SCHEMBL29964086 | 0.80 | KDM4E (0.42) | MEN1KMT2ACNR1KCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4330246-A1 | HALO-SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | Ontario Institute for Cancer Research (OICR) (CA) | 2024-03-06 | — | — | EP | disclosed |
| WO-2022226665-A1 | HALO-SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |