Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 15/20 | 0.60 |
| ▸ | PARP11 | Q9NR21 | 13/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 6/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.40 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.40 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4165821 | 0.82 | ACHE (0.54) | PARP10PARP11ACHEPARP1PDPK1 | |
| SCHEMBL31159024 | 0.82 | CLK4 (0.58) | PARP10PARP11ACHEPIM1CSNK1A1 | |
| SCHEMBL4168311 | 0.79 | PARP1 (0.60) | PARP10PARP11ACHEPARP1PDPK1 | |
| SCHEMBL30549718 | 0.79 | PARP10 (0.62) | PARP10PARP11ACHEPARP1PARP15 | |
| SCHEMBL25798343 | 0.79 | PARP10 (0.62) | PARP10PARP11ACHEPARP1PARP15 | |
| SCHEMBL24681313 | 0.79 | PARP10 (0.60) | PARP10PARP11ACHEPARP1PIM1 | |
| SCHEMBL14992245 | 0.79 | ACHE (0.51) | PARP10PARP11ACHEPARP1PDPK1 | |
| SCHEMBL2999788 | 0.75 | PARP10 (1.00) | PARP10PARP11ACHEPARP1PIM1 | |
| SCHEMBL29644368 | 0.75 | PARP10 (1.00) | PARP10PARP11ACHEPARP1PIM1 | |
| SCHEMBL5740876 | 0.74 | KDM4E (0.41) | PARP10PARP11PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4330246-A1 | HALO-SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | Ontario Institute for Cancer Research (OICR) (CA) | 2024-03-06 | — | — | EP | disclosed |
| CN-117597340-A | Substituted amino-aza-heteroaryl compounds as inhibitors of hematopoietic progenitor kinase 1 (HPK 1) | 安大略省癌症研究所(OICR) | 2024-02-23 | — | — | CN | disclosed |
| CN-117597336-A | Halogen substituted amino aza-heteroaryl compounds as inhibitors of hematopoietic progenitor kinase 1 (HPK 1) | 安大略省癌症研究所(OICR) | 2024-02-23 | — | — | CN | disclosed |
| WO-2022226665-A1 | HALO-SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |