Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27002205 | 1.00 | ADORA1 (0.42) | ADORA1PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL27002284 | 0.86 | PRMT5 (0.35) | ADORA1PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL29915079 | 0.86 | PRMT5 (0.35) | ADORA1PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL23087910 | 0.79 | ADORA1 (0.53) | ADORA1PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL23087259 | 0.79 | ADORA1 (0.44) | ADORA1PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL23087512 | 0.79 | ADORA1 (0.44) | ADORA1PDE1APDE1BPDE3BPDE1C | |
| SCHEMBL27002509 | 0.78 | JAK1 (0.34) | JAK1 | |
| SCHEMBL29915208 | 0.78 | PRMT5 (0.64) | PRMT5WDR77PARP1 | |
| SCHEMBL27002267 | 0.78 | PRMT5 (0.64) | PRMT5WDR77PARP1 | |
| SCHEMBL31496948 | 0.77 | ADORA1 (0.41) | ADORA1PDE1APDE1BPDE3BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4304720-A1 | MTA-COOPERATIVE PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2024-01-17 | — | — | EP | disclosed |
| WO-2022192745-A1 | MTA-COOPERATIVE PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-09-15 | — | — | WO | disclosed |