Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 6/20 | 0.64 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.64 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.34 |
| ▸ | CASP3 | P42574 | 2/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27002267 | 1.00 | PRMT5 (0.64) | PRMT5WDR77PARP1MAPTRECQL | |
| SCHEMBL31496831 | 0.84 | PRMT5 (0.60) | PRMT5WDR77PARP1MAPTCYP1B1 | |
| SCHEMBL23087447 | 0.84 | PRMT5 (0.69) | PRMT5WDR77PARP1MAPTRECQL | |
| SCHEMBL29735278 | 0.84 | PRMT5 (0.69) | PRMT5WDR77PARP1MAPTRECQL | |
| SCHEMBL29735135 | 0.83 | PRMT5 (0.67) | PRMT5WDR77PARP1MAPTRECQL | |
| SCHEMBL23087513 | 0.83 | PRMT5 (0.67) | PRMT5WDR77PARP1MAPTRECQL | |
| SCHEMBL23087741 | 0.83 | PRMT5 (0.64) | PRMT5WDR77PARP1CYP1B1ADRA1D | |
| SCHEMBL29735119 | 0.83 | PRMT5 (0.64) | PRMT5WDR77PARP1CYP1B1ADRA1D | |
| SCHEMBL29915065 | 0.81 | PRMT5 (0.61) | PRMT5WDR77PARP1CYP1B1ADRA1D | |
| SCHEMBL27002364 | 0.81 | PRMT5 (0.61) | PRMT5WDR77PARP1CYP1B1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4304720-A1 | MTA-COOPERATIVE PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2024-01-17 | — | — | EP | disclosed |
| WO-2022192745-A1 | MTA-COOPERATIVE PRMT5 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-09-15 | — | — | WO | disclosed |