Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | METAP2 | P50579 | 2/20 | 0.36 |
| ▸ | METAP1 | P53582 | 2/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12497089 | 1.00 | TLR8 (0.39) | TLR8MAPTAXLPRKCIGAA | |
| SCHEMBL2748326 | 0.85 | TLR8 (0.43) | TLR8MAPTAXLPRKCIGAA | |
| SCHEMBL29576809 | 0.85 | TLR8 (0.43) | TLR8MAPTAXLPRKCIGAA | |
| SCHEMBL29487149 | 0.83 | TLR8 (0.42) | TLR8MAPTAXLPRKCIGAA | |
| SCHEMBL22959954 | 0.83 | TLR8 (0.42) | TLR8MAPTAXLPRKCIGAA | |
| SCHEMBL16636981 | 0.79 | PRKCI (0.41) | TLR8MAPTAXLPRKCIKDM4E | |
| SCHEMBL18451242 | 0.79 | KMT2A (0.39) | TLR8MAPTGAAATMKDM4E | |
| SCHEMBL16604815 | 0.79 | TLR8 (0.39) | TLR8MAPTAXLPRKCIKDM4E | |
| SCHEMBL22959955 | 0.79 | ESR1 (0.39) | TLR8MAPTAXLPRKCIGAA | |
| SCHEMBL15960732 | 0.79 | TLR8 (0.52) | TLR8MAPTAXLPRKCIGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4322947-A1 | HETEROARYL COMPOUNDS AS INHIBITORS OF RIP2 KINASE, COMPOSITION AND APPLICATION THEREOF | Accro Bioscience (HK) Limited (HK) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022192760-A1 | HETEROARYL COMPOUNDS AS INHIBITORS OF RIP2 KINASE, COMPOSITION AND APPLICATION THEREOF | ACCRO BIOSCIENCE (HK) LIMITED (CN) | 2022-09-15 | — | — | WO | disclosed |