SCHEMBL29915248

SCHEMBL29915248

[2H]C([2H])([2H])N1C(=O)C(NC(=O)c2n[nH]c(Cc3ccccc3)n2)CCc2ccc(C#CC(C)(C)O)cc21

nearest known ligand 0.74

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ RIPK1 Q13546 20/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23066837 0.95 RIPK1 (0.77) RIPK1
SCHEMBL23075208 0.95 RIPK1 (0.77) RIPK1
SCHEMBL23066836 0.95 RIPK1 (0.77) RIPK1
SCHEMBL23066764 0.90 RIPK1 (0.75) RIPK1
SCHEMBL23066761 0.90 RIPK1 (0.75) RIPK1
SCHEMBL23075184 0.90 RIPK1 (0.75) RIPK1
SCHEMBL23075199 0.89 RIPK1 (0.74) RIPK1
SCHEMBL24167132 0.85 RIPK1 (1.00) RIPK1
SCHEMBL24193619 0.85 RIPK1 (1.00) RIPK1
SCHEMBL24077306 0.85 RIPK1 (0.76) RIPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115279763-A RIP1 inhibiting compounds and methods of making and using the same 里格尔药品股份有限公司 2022-11-01 — — CN claimed
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