Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 11/20 | 0.41 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21633965 | 1.00 | EPAS1 (0.47) | EPAS1TRPA1HSPB1MAP4K4L3MBTL1 | |
| SCHEMBL21652833 | 0.82 | EPAS1 (0.47) | EPAS1TRPA1HSPB1L3MBTL1MAPK14 | |
| SCHEMBL21634034 | 0.82 | EPAS1 (0.47) | EPAS1TRPA1HSPB1MAP4K4L3MBTL1 | |
| SCHEMBL29915637 | 0.78 | EPAS1 (0.55) | EPAS1TRPA1HSPB1MAP4K4L3MBTL1 | |
| SCHEMBL20384356 | 0.78 | EPAS1 (0.55) | EPAS1TRPA1HSPB1MAP4K4L3MBTL1 | |
| SCHEMBL29915547 | 0.77 | PKM (0.47) | EPAS1HSPB1PKM | |
| SCHEMBL21652832 | 0.77 | PKM (0.47) | EPAS1HSPB1PKM | |
| SCHEMBL21652788 | 0.75 | EPAS1 (0.43) | EPAS1TRPA1HSPB1MAP4K4MAPK14 | |
| SCHEMBL28388159 | 0.74 | EPAS1 (0.55) | EPAS1TRPA1HSPB1MAP4K4L3MBTL1 | |
| SCHEMBL23403939 | 0.74 | PKM (0.44) | EPAS1TRPA1HSPB1PKMMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115716827-A | Iminosulfones compound as bromodomain protein inhibitor, pharmaceutical composition and medical application thereof | 正大天晴药业集团股份有限公司 | 2023-02-28 | — | — | CN | disclosed |
| CN-112424200-B | Iminosulfones compound as bromodomain protein inhibitor, pharmaceutical composition and medical application thereof | 正大天晴药业集团股份有限公司 | 2022-09-20 | — | — | CN | disclosed |