Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | NNMT | P40261 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 1/20 | 0.41 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29923668 | 1.00 | KDM4E (0.64) | KDM4EL3MBTL1NNMTSMN1; SMN2GRM5 | |
| SCHEMBL845436 | 0.82 | P4HA1 (0.55) | KDM4EL3MBTL1 | |
| SCHEMBL4756343 | 0.82 | KDM4E (0.66) | KDM4EL3MBTL1NNMTSMN1; SMN2GRM5 | |
| SCHEMBL31003291 | 0.81 | KCNJ1 (0.42) | KDM4EL3MBTL1SMN1; SMN2 | |
| SCHEMBL21581694 | 0.81 | UBE2T (0.45) | KDM4EL3MBTL1 | |
| SCHEMBL932013 | 0.81 | KCNJ1 (0.42) | KDM4EL3MBTL1SMN1; SMN2 | |
| SCHEMBL846377 | 0.77 | MAPK1 (0.59) | KDM4EL3MBTL1HPGDS | |
| SCHEMBL1515578 | 0.77 | KDM4E (0.58) | KDM4EL3MBTL1NNMTSMN1; SMN2GRM5 | |
| SCHEMBL31601570 | 0.77 | MAPK1 (0.59) | KDM4EL3MBTL1HPGDS | |
| SCHEMBL27876298 | 0.77 | KDM4E (0.46) | KDM4EL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3798214-B1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2022-09-14 | — | — | EP | claimed |