Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 5/20 | 0.42 |
| ▸ | FLT4 | P35916 | 5/20 | 0.42 |
| ▸ | KDR | P35968 | 5/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | GRK5 | P34947 | 1/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17647029 | 1.00 | PTGS2 (0.47) | PTGS2PTGS1KAT6AFLT1FLT4 | |
| SCHEMBL17647834 | 0.92 | PTGS2 (0.49) | PTGS2PTGS1KAT6AFLT1FLT4 | |
| SCHEMBL29915808 | 0.92 | PTGS2 (0.49) | PTGS2PTGS1KAT6AFLT1FLT4 | |
| SCHEMBL29916455 | 0.91 | FLT1 (0.47) | PTGS2PTGS1KAT6AFLT1FLT4 | |
| SCHEMBL17647093 | 0.91 | FLT1 (0.47) | PTGS2PTGS1KAT6AFLT1FLT4 | |
| SCHEMBL29917227 | 0.91 | FLT1 (0.46) | PTGS2PTGS1KAT6AFLT1FLT4 | |
| SCHEMBL17648857 | 0.91 | FLT1 (0.46) | PTGS2PTGS1KAT6AFLT1FLT4 | |
| SCHEMBL17647886 | 0.90 | KAT6A (0.43) | PTGS2PTGS1KAT6AFLT1FLT4 | |
| SCHEMBL29917405 | 0.90 | PPARG (0.43) | PTGS2PTGS1KAT6AFLT1FLT4 | |
| SCHEMBL17648202 | 0.90 | PPARG (0.43) | PTGS2PTGS1KAT6AFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3798214-B1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2022-09-14 | — | — | EP | claimed |