Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 5/20 | 0.46 |
| ▸ | FLT4 | P35916 | 5/20 | 0.46 |
| ▸ | KDR | P35968 | 5/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17649787 | 1.00 | FLT1 (0.46) | FLT1FLT4KDRPLAUPRKAB2 | |
| SCHEMBL29915808 | 0.91 | PTGS2 (0.49) | FLT1FLT4KDRPTGS1PTGS2 | |
| SCHEMBL17647834 | 0.91 | PTGS2 (0.49) | FLT1FLT4KDRPTGS1PTGS2 | |
| SCHEMBL29916455 | 0.90 | FLT1 (0.47) | FLT1FLT4KDRPPARGPTGS1 | |
| SCHEMBL17647093 | 0.90 | FLT1 (0.47) | FLT1FLT4KDRPPARGPTGS1 | |
| SCHEMBL17648857 | 0.90 | FLT1 (0.46) | FLT1FLT4KDRPTGS1PTGS2 | |
| SCHEMBL29917227 | 0.90 | FLT1 (0.46) | FLT1FLT4KDRPTGS1PTGS2 | |
| SCHEMBL17647135 | 0.89 | FLT1 (0.48) | FLT1FLT4KDRPTGS1PTGS2 | |
| SCHEMBL29917687 | 0.89 | FLT1 (0.48) | FLT1FLT4KDRPTGS1PTGS2 | |
| SCHEMBL17647029 | 0.89 | PTGS2 (0.47) | FLT1FLT4KDRPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3798214-B1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2022-09-14 | — | — | EP | claimed |