Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 9/20 | 0.40 |
| ▸ | FLT4 | P35916 | 9/20 | 0.40 |
| ▸ | KDR | P35968 | 9/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17647852 | 1.00 | FLT1 (0.40) | FLT1FLT4KDRPTGS1PTGS2 | |
| SCHEMBL29917825 | 0.92 | KAT6A (0.41) | FLT1FLT4KDRPTGS1PTGS2 | |
| SCHEMBL17648386 | 0.92 | KAT6A (0.41) | FLT1FLT4KDRPTGS1PTGS2 | |
| SCHEMBL29917852 | 0.92 | KAT6A (0.41) | FLT1FLT4KDRPTGS1PTGS2 | |
| SCHEMBL17648164 | 0.92 | KAT6A (0.41) | FLT1FLT4KDRPTGS1PTGS2 | |
| SCHEMBL29915808 | 0.91 | PTGS2 (0.49) | FLT1FLT4KDRPTGS1PTGS2 | |
| SCHEMBL17647834 | 0.91 | PTGS2 (0.49) | FLT1FLT4KDRPTGS1PTGS2 | |
| SCHEMBL17648529 | 0.89 | FLT1 (0.47) | FLT1FLT4KDRPTGS1PTGS2 | |
| SCHEMBL29915842 | 0.89 | FLT1 (0.47) | FLT1FLT4KDRPTGS1PTGS2 | |
| SCHEMBL17649277 | 0.89 | PTGS2 (0.44) | FLT1FLT4KDRPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3798214-B1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2022-09-14 | — | — | EP | claimed |