Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 10/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | PDCD1LG2 | Q9BQ51 | 5/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.33 |
| ▸ | FLT1 | P17948 | 2/20 | 0.33 |
| ▸ | FLT4 | P35916 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17649011 | 1.00 | SCN9A (0.35) | SCN9ASCN5APDCD1LG2CD274FLT1 | |
| SCHEMBL17647916 | 0.92 | RAB9A (0.39) | SCN9ASCN5AFLT1FLT4KDR | |
| SCHEMBL29917313 | 0.92 | RAB9A (0.39) | SCN9ASCN5AFLT1FLT4KDR | |
| SCHEMBL19440522 | 0.91 | SCN9A (0.34) | SCN9ASCN5AFLT1FLT4KDR | |
| SCHEMBL29918019 | 0.91 | MAPT (0.35) | SCN9ASCN5APDCD1LG2CD274FLT1 | |
| SCHEMBL17648396 | 0.91 | MAPT (0.35) | SCN9ASCN5APDCD1LG2CD274FLT1 | |
| SCHEMBL17648558 | 0.90 | EGFR (0.36) | SCN9ASCN5APDCD1LG2CD274FLT1 | |
| SCHEMBL29916753 | 0.90 | EGFR (0.36) | SCN9ASCN5APDCD1LG2CD274FLT1 | |
| SCHEMBL17648222 | 0.90 | CD274 (0.37) | SCN9ASCN5APDCD1LG2CD274NPC1 | |
| SCHEMBL29916237 | 0.90 | CD274 (0.37) | SCN9ASCN5APDCD1LG2CD274NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3798214-B1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2022-09-14 | — | — | EP | claimed |