Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 5/20 | 0.72 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.72 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.72 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.72 |
| ▸ | SYK | P43405 | 6/20 | 0.53 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | VNN1 | O95497 | 2/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.44 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.44 |
| ▸ | NNMT | P40261 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4730352 | 0.84 | HDAC1 (1.00) | HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL4485439 | 0.82 | SYK (0.59) | HDAC3HDAC1HDAC2HDAC6SYK | |
| SCHEMBL2103980 | 0.77 | AURKA (0.70) | SYK | |
| SCHEMBL14658780 | 0.73 | MAPK8 (0.74) | SYKZAP70 | |
| SCHEMBL10975772 | 0.73 | HDAC3 (0.60) | HDAC3HDAC1HDAC2HDAC6SYK | |
| SCHEMBL8739793 | 0.72 | HDAC3 (1.00) | HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL4487993 | 0.72 | HDAC6 (0.68) | HDAC3HDAC1HDAC2HDAC6SYK | |
| SCHEMBL894796 | 0.72 | PARP1 (0.64) | PLAUHPGDS | |
| SCHEMBL30033167 | 0.72 | SYK (0.54) | HDAC3HDAC1HDAC2HDAC6SYK | |
| SCHEMBL3634270 | 0.71 | HDAC3 (0.74) | HDAC3HDAC1HDAC2HDAC6SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115073467-B | Pyrimidine imidazole compound, and pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2024-03-15 | — | — | CN | disclosed |
| CN-115073467-A | Pyrimido imidazole compound and medicinal composition and application thereof | 中国科学院上海药物研究所 | 2022-09-20 | — | — | CN | disclosed |