Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 16/20 | 0.75 |
| ▸ | BRD4 | O60885 | 8/20 | 0.75 |
| ▸ | BRDT | Q58F21 | 8/20 | 0.75 |
| ▸ | RAD52 | P43351 | 1/20 | 0.67 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.62 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.61 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.60 |
| ▸ | PDXK | O00764 | 1/20 | 0.60 |
| ▸ | CIT | O14578 | 1/20 | 0.60 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.60 |
| ▸ | GAK | O14976 | 1/20 | 0.60 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.60 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.60 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.60 |
| ▸ | STK16 | O75716 | 1/20 | 0.60 |
| ▸ | STK10 | O94804 | 1/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Plogosertib SCHEMBL1202855 | 1.00 | PLK1 (0.75) | PLK1BRD4BRDTRAD52PLK3 | |
| Plogosertib SCHEMBL12879990 | 1.00 | PLK1 (0.75) | PLK1BRD4BRDTRAD52PLK3 | |
| Plogosertib SCHEMBL1202614 | 1.00 | PLK1 (0.75) | PLK1BRD4BRDTRAD52PLK3 | |
| SCHEMBL12880560 | 0.96 | PLK1 (0.73) | PLK1BRD4BRDTRAD52PLK3 | |
| SCHEMBL12880559 | 0.96 | PLK1 (0.73) | PLK1BRD4BRDTRAD52PLK3 | |
| SCHEMBL2401008 | 0.94 | PLK1 (0.84) | PLK1BRD4BRDTRAD52PLK3 | |
| SCHEMBL2399362 | 0.94 | PLK1 (0.77) | PLK1BRD4BRDTRAD52PLK3 | |
| SCHEMBL1203741 | 0.94 | PLK1 (0.69) | PLK1BRD4BRDTRAD52PLK3 | |
| SCHEMBL12879981 | 0.94 | PLK1 (0.69) | PLK1BRD4BRDTRAD52PLK3 | |
| SCHEMBL1203630 | 0.94 | PLK1 (0.69) | PLK1BRD4BRDTRAD52PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12534466-B2 | Crystalline forms of pyrimidino diazepine derivative | CYCLACEL PHARMACEUTICALS INC. (US) | 2026-01-27 | — | — | US | disclosed |
| US-20220281880-A1 | CRYSTALLINE FORMS OF PYRIMIDINO DIAZEPINE DERIVATIVE | TETHRA BIOSCIENCES INC. | 2022-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12534466-B2 | Crystalline forms of pyrimidino diazepine derivative | PLK1, BUB1, CDC25C | PLK1 1/4885BRD4 612/4885BRDT 427/4885 |
| US-20220281880-A1 | CRYSTALLINE FORMS OF PYRIMIDINO DIAZEPINE DERIVATIVE | PDCD5, NLRP3, PDCD1 | PLK1 635/4885BRD4 352/4885BRDT 276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.