SCHEMBL29920129

SCHEMBL29920129

Nc1nc(=O)n2c(n1)oc1ccccc12

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.54
RAB9A P51151 1/20 0.54
HPGD P15428 4/20 0.38
MAPK1 P28482 3/20 0.38
TSHR P16473 3/20 0.38
USP2 O75604 2/20 0.38
ALDH1A1 P00352 4/20 0.37
NPSR1 Q6W5P4 3/20 0.37
LMNA P02545 2/20 0.37
HSD17B10 Q99714 2/20 0.37
KDM4E B2RXH2 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.34
POLB P06746 2/20 0.34
MIF P14174 1/20 0.34
IDO1 P14902 2/20 0.33
MAPT P10636 1/20 0.33
GABRP O00591 2/20 0.32
GABRD O14764 2/20 0.32
GABRA1 P14867 2/20 0.32
GABRB1 P18505 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23076234 1.00 NPC1 (0.54) NPC1RAB9AHPGDMAPK1TSHR
SCHEMBL10804413 0.75 MEN1 (0.47) NPC1RAB9A
SCHEMBL19233775 0.72 NPC1 (0.48) NPC1RAB9AHPGDMAPK1TSHR
SCHEMBL824419 0.72 NPC1 (0.63) NPC1RAB9AHPGDMAPK1TSHR
SCHEMBL19233777 0.72 NPC1 (0.48) NPC1RAB9AHPGDMAPK1TSHR
SCHEMBL17491659 0.70 NPC1 (0.66) NPC1RAB9AHPGDMAPK1TSHR
SCHEMBL19729626 0.70 NPC1 (0.49) NPC1RAB9AHPGDMAPK1ALDH1A1
SCHEMBL12289824 0.70 NPC1 (1.00) NPC1RAB9AHPGDTSHRUSP2
SCHEMBL23295693 0.70 NPC1 (0.52) NPC1RAB9AHPGDMAPK1TSHR
SCHEMBL23076374 0.69 NPC1 (0.47) NPC1RAB9AHPGDTSHRUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4025566-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES Merck Patent GmbH (DE) 2022-07-13 EP disclosed