Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.54 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20523662 | 1.00 | CHRNB4 (0.54) | CHRNB4CHRNA3MAPTMEN1KMT2A | |
| SCHEMBL6016562 | 0.87 | MAPT (0.59) | MAPTMEN1KMT2APTGS2ALDH1A1 | |
| SCHEMBL11055090 | 0.87 | MAPT (0.59) | MAPTMEN1KMT2APTGS2ALDH1A1 | |
| SCHEMBL26454103 | 0.86 | CHRNB4 (0.49) | CHRNB4CHRNA3MAPTMEN1KMT2A | |
| SCHEMBL14094967 | 0.85 | CHRNB4 (0.51) | CHRNB4CHRNA3MAPTMEN1KMT2A | |
| SCHEMBL30935091 | 0.82 | CHRNB4 (0.54) | CHRNB4CHRNA3MAPTMEN1KMT2A | |
| SCHEMBL16116282 | 0.81 | CHRNB4 (0.50) | CHRNB4CHRNA3MAPTMEN1KMT2A | |
| SCHEMBL16958006 | 0.81 | TSHR (0.59) | MAPTMEN1KMT2APTGS2ALDH1A1 | |
| SCHEMBL282545 | 0.80 | LMNA (0.49) | CHRNB4CHRNA3MAPTMEN1KMT2A | |
| SCHEMBL29920077 | 0.80 | LMNA (0.49) | CHRNB4CHRNA3MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4319756-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| WO-2022217276-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-10-13 | — | — | WO | disclosed |