Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.68 |
| ▸ | GRK2 | P25098 | 4/20 | 0.56 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | KLK1 | P06870 | 1/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3164681 | 1.00 | TAAR1 (0.68) | TAAR1GRK2CACNA1BROCK2KLK1 | |
| SCHEMBL3164273 | 0.86 | TAAR1 (0.63) | TAAR1GRK2ROCK2FFAR1F2 | |
| SCHEMBL3171172 | 0.85 | TAAR1 (0.61) | TAAR1GRK2ROCK2KLK1KLK5 | |
| SCHEMBL2472175 | 0.85 | TAAR1 (0.61) | TAAR1GRK2ROCK2KLK1KLK5 | |
| SCHEMBL3166154 | 0.82 | TAAR1 (1.00) | TAAR1GRK2ROCK2KLK1KLK5 | |
| SCHEMBL13451067 | 0.77 | TAAR1 (0.67) | TAAR1GRK2ROCK2KLK1KLK5 | |
| SCHEMBL3155469 | 0.77 | TAAR1 (0.67) | TAAR1KLK1KLK5ALDH1A1KDM4E | |
| SCHEMBL3171445 | 0.77 | TAAR1 (0.67) | TAAR1KLK1KLK5ALDH1A1KDM4E | |
| SCHEMBL2473036 | 0.77 | TAAR1 (0.67) | TAAR1GRK2ROCK2KLK1KLK5 | |
| SCHEMBL5693016 | 0.77 | TAAR1 (0.67) | TAAR1KLK1KLK5ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220280527-A1 | TRACE AMINE ASSOCIATED RECEPTOR 1 AGONISTS AND PARTIAL AGONISTS FOR PAIN TREATMENT | PURDUE PHARMA L.P. (US) | 2022-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220280527-A1 | TRACE AMINE ASSOCIATED RECEPTOR 1 AGONISTS AND PARTIAL AGONISTS FOR PAIN TREATMENT | TAAR1, TAAR5, OPRL1 | TAAR1 1/4885GRK2 247/4885CACNA1B 255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.