Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15557358 | 0.88 | HTT (0.51) | MAPTL3MBTL1POLBHTTPIK3CA | |
| SCHEMBL27086630 | 0.81 | MAPT (0.45) | MAPTL3MBTL1POLBHTTPIK3CA | |
| SCHEMBL477324 | 0.77 | HSD17B10 (0.44) | MAPTL3MBTL1HTTKDM4EMEN1 | |
| SCHEMBL28604242 | 0.76 | L3MBTL1 (0.53) | MAPTL3MBTL1POLBHTTPIK3CA | |
| SCHEMBL29931675 | 0.73 | MAPT (0.52) | MAPTL3MBTL1HTTPIK3CAKDM4E | |
| SCHEMBL1308905 | 0.73 | MAPT (0.61) | MAPTL3MBTL1POLBHTTPIK3CA | |
| SCHEMBL14993344 | 0.71 | POLB (0.60) | POLBHTTAKR1C3 | |
| SCHEMBL909718 | 0.70 | USP2 (0.56) | MAPTL3MBTL1HTTPIK3CAMTOR | |
| SCHEMBL17748676 | 0.70 | PIK3CA (0.46) | PIK3CAMTORPIK3CG | |
| SCHEMBL38827 | 0.70 | MAPT (0.57) | MAPTL3MBTL1POLBHTTPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320110-A1 | TRIAZINE DERIVATIVE AS COVALENT INHIBITORS OF PI3K | Universität Basel (CH) | 2024-02-14 | — | — | EP | disclosed |
| EP-4320115-A1 | TRIAZINE DERIVATIVE AS REVERSIBLE AND IRREVERSIBLE COVALENT INHIBITORS OF PI3K | Universität Basel (CH) | 2024-02-14 | — | — | EP | disclosed |
| WO-2022214701-A1 | TRIAZINE DERIVATIVE AS COVALENT INHIBITORS OF PI3K | UNIVERSITÄT BASEL (CH) | 2022-10-13 | — | — | WO | disclosed |
| WO-2022214702-A1 | TRIAZINE DERIVATIVE AS REVERSIBLE AND IRREVERSIBLE COVALENT INHIBITORS OF PI3K | UNIVERSITÄT BASEL (CH) | 2022-10-13 | — | — | WO | disclosed |