Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.51 |
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.51 |
| ▸ | MAP4K3 | Q8IVH8 | 7/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28459567 | 1.00 | IRAK4 (0.51) | IRAK4MAP4K1MAP4K3AURKARPS6KB1 | |
| SCHEMBL22773044 | 1.00 | IRAK4 (0.51) | IRAK4MAP4K1MAP4K3AURKARPS6KB1 | |
| SCHEMBL29922290 | 0.90 | RPS6KB1 (0.56) | IRAK4MAP4K1MAP4K3AURKARPS6KB1 | |
| SCHEMBL29922295 | 0.89 | AURKA (0.47) | IRAK4MAP4K1MAP4K3AURKARPS6KB1 | |
| SCHEMBL29261531 | 0.85 | IRAK4 (0.40) | IRAK4MAP4K1MAP4K3AURKARPS6KB1 | |
| SCHEMBL29261529 | 0.85 | IRAK4 (0.40) | IRAK4MAP4K1MAP4K3AURKARPS6KB1 | |
| SCHEMBL24612853 | 0.85 | MAP4K1 (0.56) | IRAK4MAP4K1MAP4K3AURKARPS6KB1 | |
| SCHEMBL22785699 | 0.85 | MAP4K1 (0.56) | IRAK4MAP4K1MAP4K3AURKARPS6KB1 | |
| SCHEMBL30504131 | 0.85 | MAP4K1 (0.56) | IRAK4MAP4K1MAP4K3AURKARPS6KB1 | |
| SCHEMBL30431469 | 0.85 | MAP4K1 (0.56) | IRAK4MAP4K1MAP4K3AURKARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022188735-A1 | HETEROCYCLIC COMPOUNDS AS HPK1 INHIBITORS | GUANGDONG NEWOPP BIOPHARMACEUTICALS CO., LTD. (CN) | 2022-09-15 | — | — | WO | disclosed |