Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLCO1B1 | Q9Y6L6 | 3/20 | 0.33 |
| ▸ | ABCC3 | O15438 | 2/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.33 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.31 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PDE8B | O95263 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27157558 | 1.00 | SLCO1B1 (0.33) | SLCO1B1ABCC3ABCC4SLCO1B3TGFBR1 | |
| SCHEMBL30821872 | 0.94 | ABCC3 (0.33) | SLCO1B1ABCC3ABCC4SLCO1B3ABCB11 | |
| SCHEMBL29180491 | 0.89 | PDE8B (0.33) | TGFBR1TGFBR2ADORA3KDM4CNPC1 | |
| SCHEMBL30740284 | 0.89 | PDE8B (0.33) | TGFBR1TGFBR2ADORA3KDM4CNPC1 | |
| SCHEMBL29067956 | 0.89 | SLCO1B1 (0.33) | SLCO1B1ABCC3ABCC4SLCO1B3TGFBR1 | |
| SCHEMBL19715601 | 0.88 | SLCO1B1 (0.36) | SLCO1B1ABCC3ABCC4SLCO1B3TGFBR1 | |
| SCHEMBL19715663 | 0.88 | MIF (0.31) | SLCO1B1ABCC3ABCC4SLCO1B3TGFBR1 | |
| SCHEMBL29068035 | 0.86 | SLCO1B1 (0.32) | SLCO1B1ABCC3ABCC4SLCO1B3TGFBR1 | |
| SCHEMBL30452885 | 0.86 | SLCO1B1 (0.32) | SLCO1B1ABCC3ABCC4SLCO1B3TGFBR1 | |
| SCHEMBL30454078 | 0.85 | SLCO1B1 (0.32) | SLCO1B1ABCC3ABCC4SLCO1B3TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117751106-A | Novel triazole-pyridine substituted pyrrolidinyl and tetrahydro-2H-pyranylacetic acid compounds as LPA antagonists | 唯久生物技术(苏州)有限公司 | 2024-03-22 | — | — | CN | disclosed |
| EP-4330249-A1 | NOVEL TRIAZOLE-PYRIDINE SUBSTITUTED PYRROLIDINYL AND TETRAHYDRO-2H-PYRANYL ACETIC ACID COMPOUNDS AS LPA ANTAGONISTS | Viva Star Biosciences (Suzhou) Co., Ltd. (CN) | 2024-03-06 | — | — | EP | disclosed |
| WO-2024022314-A1 | TRIAZOLE COMPOUNDS AND USE THEREOF AS LPAR1 ANTAGONIST | 武汉人福创新药物研发中心有限公司 | 2024-02-01 | — | — | WO | disclosed |
| CN-117447450-A | Triazole compounds and their use as LPAR1 antagonists | 武汉人福创新药物研发中心有限公司 | 2024-01-26 | — | — | CN | disclosed |
| CN-116669727-A | Triazole-pyridinyl substituted azacyclohexylacetic acid compounds as LPA receptor antagonists | 唯久生物有限公司 | 2023-08-29 | — | — | CN | disclosed |
| EP-4196220-A1 | TRIAZOLE-PYRIDINYL SUBSTITUTED AZACYCLOHEXYL ACETIC ACID COMPOUNDS AS LPA RECEPTOR ANTAGONISTS | Viva Star Biosciences Limited (HK) | 2023-06-21 | — | — | EP | disclosed |
| WO-2022232459-A1 | NOVEL TRIAZOLE-PYRIDINE SUBSTITUTED PYRROLIDINYL AND TETRAHYDRO-2H-PYRANYL ACETIC ACID COMPOUNDS AS LPA ANTAGONISTS | VIVA STAR BIOSCIENCES (SUZHOU) CO., LTD. (CN) | 2022-11-03 | — | — | WO | disclosed |