Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.61 |
| ▸ | JAK1 | P23458 | 10/20 | 0.61 |
| ▸ | TYK2 | P29597 | 10/20 | 0.61 |
| ▸ | JAK3 | P52333 | 10/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.41 |
| ▸ | CSF1R | P07333 | 4/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29922656 | 0.81 | JAK2 (0.42) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29922505 | 0.80 | JAK2 (0.46) | JAK2JAK1TYK2JAK3PDE4B | |
| SCHEMBL29922706 | 0.80 | JAK2 (0.43) | JAK2JAK1TYK2JAK3PDE4B | |
| SCHEMBL29922714 | 0.80 | JAK2 (0.47) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29923095 | 0.80 | JAK2 (0.66) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL29922700 | 0.80 | JAK2 (0.43) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29922684 | 0.78 | TYK2 (0.40) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL28359124 | 0.78 | JAK2 (0.66) | JAK2JAK1TYK2JAK3PDE4B | |
| SCHEMBL29922608 | 0.77 | JAK2 (0.39) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29922762 | 0.77 | JAK2 (0.46) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |