Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.66 |
| ▸ | JAK1 | P23458 | 5/20 | 0.66 |
| ▸ | TYK2 | P29597 | 5/20 | 0.66 |
| ▸ | JAK3 | P52333 | 5/20 | 0.66 |
| ▸ | STAT6 | P42226 | 5/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922727 | 0.90 | JAK2 (0.55) | JAK2JAK1TYK2JAK3AURKA | |
| SCHEMBL29922737 | 0.83 | TYK2 (0.67) | JAK2JAK1TYK2JAK3STAT6 | |
| SCHEMBL29922801 | 0.83 | RAB9A (0.54) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29922714 | 0.83 | JAK2 (0.47) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29922918 | 0.81 | JAK2 (0.44) | JAK2JAK1TYK2JAK3FGFR1 | |
| SCHEMBL29922528 | 0.81 | JAK3 (0.45) | JAK2JAK1TYK2JAK3MAPK9 | |
| SCHEMBL29922596 | 0.80 | JAK2 (0.61) | JAK2JAK1TYK2JAK3LRRK2 | |
| SCHEMBL29922682 | 0.80 | TYK2 (0.51) | JAK2JAK1TYK2JAK3STAT6 | |
| SCHEMBL28359087 | 0.79 | TYK2 (1.00) | JAK2JAK1TYK2JAK3STAT6 | |
| SCHEMBL29922509 | 0.77 | TYK2 (0.52) | JAK2JAK1TYK2JAK3STAT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |