Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 4/20 | 0.54 |
| ▸ | JAK2 | O60674 | 3/20 | 0.54 |
| ▸ | JAK1 | P23458 | 3/20 | 0.54 |
| ▸ | JAK3 | P52333 | 3/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28362774 | 1.00 | TYK2 (0.54) | TYK2JAK2JAK1JAK3PTGS2 | |
| SCHEMBL28358976 | 0.93 | JAK2 (0.44) | TYK2JAK2JAK1JAK3MAPT | |
| SCHEMBL29922647 | 0.93 | JAK2 (0.44) | TYK2JAK2JAK1JAK3MAPT | |
| SCHEMBL29552110 | 0.90 | JAK2 (0.55) | TYK2JAK2JAK1JAK3PTGS2 | |
| SCHEMBL28359246 | 0.86 | JAK2 (0.54) | TYK2JAK2JAK1JAK3PTGS2 | |
| SCHEMBL29552137 | 0.86 | JAK2 (0.54) | TYK2JAK2JAK1JAK3PTGS2 | |
| SCHEMBL28358944 | 0.84 | JAK2 (0.51) | TYK2JAK2JAK1JAK3MAPT | |
| SCHEMBL29922577 | 0.84 | JAK2 (0.51) | TYK2JAK2JAK1JAK3MAPT | |
| SCHEMBL28362763 | 0.82 | JAK2 (0.59) | TYK2JAK2JAK1JAK3MAPT | |
| SCHEMBL29551959 | 0.82 | JAK2 (0.46) | TYK2JAK2JAK1JAK3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |