Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.44 |
| ▸ | TYK2 | P29597 | 9/20 | 0.44 |
| ▸ | JAK1 | P23458 | 5/20 | 0.44 |
| ▸ | JAK3 | P52333 | 5/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28358976 | 1.00 | JAK2 (0.44) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL28362774 | 0.93 | TYK2 (0.54) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL29922630 | 0.93 | TYK2 (0.54) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL29551959 | 0.89 | JAK2 (0.46) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL29552340 | 0.85 | DHODH (0.45) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL28362738 | 0.85 | DHODH (0.45) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL28359104 | 0.85 | TYK2 (0.50) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL29922784 | 0.85 | DHODH (0.45) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL28359015 | 0.85 | TYK2 (0.44) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL28362639 | 0.85 | JAK2 (0.44) | JAK2TYK2JAK1JAK3DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |