Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 10/20 | 0.63 |
| ▸ | JAK3 | P52333 | 10/20 | 0.63 |
| ▸ | JAK2 | O60674 | 9/20 | 0.63 |
| ▸ | JAK1 | P23458 | 9/20 | 0.63 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922889 | 0.89 | JAK2 (0.52) | TYK2JAK3JAK2JAK1SYK | |
| SCHEMBL29922762 | 0.82 | JAK2 (0.46) | TYK2JAK3JAK2JAK1SYK | |
| SCHEMBL28359121 | 0.79 | TYK2 (0.64) | TYK2JAK3JAK2JAK1CDK1 | |
| SCHEMBL29922700 | 0.79 | JAK2 (0.43) | TYK2JAK3JAK2JAK1HDAC6 | |
| SCHEMBL3121172 | 0.78 | JAK2 (1.00) | TYK2JAK3JAK2JAK1 | |
| SCHEMBL29922608 | 0.76 | JAK2 (0.39) | TYK2JAK3JAK2JAK1 | |
| SCHEMBL20093309 | 0.74 | JAK2 (0.89) | TYK2JAK3JAK2JAK1 | |
| SCHEMBL29922753 | 0.74 | JAK3 (0.34) | TYK2JAK3JAK2JAK1LCK | |
| SCHEMBL29922592 | 0.73 | JAK2 (0.39) | TYK2JAK3JAK2JAK1 | |
| SCHEMBL29922684 | 0.73 | TYK2 (0.40) | TYK2JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |