Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.52 |
| ▸ | JAK1 | P23458 | 12/20 | 0.52 |
| ▸ | TYK2 | P29597 | 12/20 | 0.52 |
| ▸ | JAK3 | P52333 | 12/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | WEE1 | P30291 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922637 | 0.89 | TYK2 (0.63) | JAK2JAK1TYK2JAK3SYK | |
| SCHEMBL29922762 | 0.82 | JAK2 (0.46) | JAK2JAK1TYK2JAK3SYK | |
| SCHEMBL29922887 | 0.82 | JAK1 (0.40) | JAK2JAK1TYK2JAK3SYK | |
| SCHEMBL28362673 | 0.79 | JAK2 (0.59) | JAK2JAK1TYK2JAK3IDO1 | |
| SCHEMBL29922700 | 0.79 | JAK2 (0.43) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29922923 | 0.77 | JAK2 (0.40) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29922682 | 0.76 | TYK2 (0.51) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29922608 | 0.76 | JAK2 (0.39) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29922801 | 0.76 | RAB9A (0.54) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29923095 | 0.75 | JAK2 (0.66) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |