Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 2/20 | 0.68 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.68 |
| ▸ | VHL | P40337 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | ELOC | Q15369 | 1/20 | 0.37 |
| ▸ | ELOB | Q15370 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL409250 | 0.92 | P2RX3 (0.79) | P2RX3P2RX2 | |
| SCHEMBL406899 | 0.81 | P2RX3 (1.00) | P2RX3P2RX2HRH3 | |
| SCHEMBL10188012 | 0.80 | P2RX3 (0.79) | P2RX3P2RX2 | |
| SCHEMBL10187925 | 0.78 | P2RX3 (0.58) | P2RX3P2RX2 | |
| SCHEMBL408698 | 0.78 | P2RX3 (0.58) | P2RX3P2RX2 | |
| SCHEMBL409357 | 0.78 | P2RX3 (0.58) | P2RX3P2RX2 | |
| SCHEMBL2355771 | 0.77 | P2RX3 (0.48) | P2RX3P2RX2 | |
| SCHEMBL409366 | 0.74 | P2RX3 (0.70) | P2RX3P2RX2 | |
| SCHEMBL408812 | 0.74 | P2RX3 (0.70) | P2RX3P2RX2 | |
| SCHEMBL404560 | 0.72 | P2RX3 (0.67) | P2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786110-B2 | Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC (US) | 2010-08-31 | — | — | US | claimed |