Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.46 |
| ▸ | JAK1 | P23458 | 4/20 | 0.46 |
| ▸ | TYK2 | P29597 | 4/20 | 0.46 |
| ▸ | JAK3 | P52333 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 7/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922823 | 0.84 | JAK2 (0.51) | JAK2JAK1TYK2JAK3MAPK8 | |
| SCHEMBL29552483 | 0.84 | JAK2 (0.52) | JAK2JAK1TYK2JAK3SIRT2 | |
| SCHEMBL28362644 | 0.84 | JAK2 (0.52) | JAK2JAK1TYK2JAK3SIRT2 | |
| SCHEMBL28358981 | 0.83 | JAK1 (0.47) | JAK2JAK1TYK2JAK3MAPT | |
| SCHEMBL29551854 | 0.83 | JAK1 (0.47) | JAK2JAK1TYK2JAK3MAPT | |
| SCHEMBL29552324 | 0.82 | JAK2 (0.48) | JAK2JAK1TYK2JAK3SYK | |
| SCHEMBL28359105 | 0.82 | JAK2 (0.48) | JAK2JAK1TYK2JAK3SYK | |
| SCHEMBL28362682 | 0.81 | TYK2 (0.58) | JAK2JAK1TYK2JAK3SYK | |
| SCHEMBL29552312 | 0.81 | TYK2 (0.58) | JAK2JAK1TYK2JAK3SYK | |
| SCHEMBL29552169 | 0.81 | TYK2 (0.58) | JAK2JAK1TYK2JAK3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |