Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.51 |
| ▸ | JAK1 | P23458 | 3/20 | 0.51 |
| ▸ | TYK2 | P29597 | 3/20 | 0.51 |
| ▸ | JAK3 | P52333 | 3/20 | 0.51 |
| ▸ | FABP4 | P15090 | 6/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 2/20 | 0.42 |
| ▸ | FABP3 | P05413 | 2/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29922680 | 0.92 | JAK2 (0.58) | JAK2JAK1TYK2JAK3FABP4 | |
| SCHEMBL29551888 | 0.85 | JAK2 (0.59) | JAK2JAK1TYK2JAK3DHODH | |
| SCHEMBL29922812 | 0.84 | MAPT (0.53) | JAK2JAK1TYK2JAK3DHODH | |
| SCHEMBL29922831 | 0.84 | JAK2 (0.52) | JAK2JAK1TYK2JAK3DHODH | |
| SCHEMBL29922653 | 0.84 | JAK2 (0.46) | JAK2JAK1TYK2JAK3DHODH | |
| SCHEMBL28359236 | 0.81 | TYK2 (0.58) | JAK2JAK1TYK2JAK3DHODH | |
| SCHEMBL29552249 | 0.81 | TYK2 (0.58) | JAK2JAK1TYK2JAK3DHODH | |
| SCHEMBL28362555 | 0.81 | JAK1 (0.52) | JAK2JAK1TYK2JAK3CDC25B | |
| SCHEMBL29551925 | 0.81 | JAK1 (0.52) | JAK2JAK1TYK2JAK3CDC25B | |
| SCHEMBL29551873 | 0.78 | TYK2 (0.52) | JAK2JAK1TYK2JAK3DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |