Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.42 |
| ▸ | TYK2 | P29597 | 6/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28362586 | 1.00 | JAK2 (0.42) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL29922940 | 0.94 | JAK2 (0.49) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL28359019 | 0.94 | JAK2 (0.49) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL29552218 | 0.91 | JAK2 (0.43) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL28362534 | 0.90 | JAK2 (0.51) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL29552328 | 0.90 | JAK2 (0.51) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL29552272 | 0.85 | JAK2 (0.50) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL29552451 | 0.84 | JAK2 (0.60) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL28359233 | 0.84 | TYK2 (0.40) | JAK2TYK2JAK1JAK3DHODH | |
| SCHEMBL29922893 | 0.84 | TYK2 (0.40) | JAK2TYK2JAK1JAK3DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |