Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.49 |
| ▸ | TYK2 | P29597 | 4/20 | 0.49 |
| ▸ | JAK1 | P23458 | 3/20 | 0.49 |
| ▸ | JAK3 | P52333 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28359019 | 1.00 | JAK2 (0.49) | JAK2TYK2JAK1JAK3MAPT | |
| SCHEMBL28362586 | 0.94 | JAK2 (0.42) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL29922686 | 0.94 | JAK2 (0.42) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL29552272 | 0.92 | JAK2 (0.50) | JAK2TYK2JAK1JAK3MAPT | |
| SCHEMBL28359046 | 0.91 | JAK2 (0.60) | JAK2TYK2JAK1JAK3MAPT | |
| SCHEMBL29552451 | 0.91 | JAK2 (0.60) | JAK2TYK2JAK1JAK3MAPT | |
| SCHEMBL29922577 | 0.88 | JAK2 (0.51) | JAK2TYK2JAK1JAK3MAPT | |
| SCHEMBL28358944 | 0.88 | JAK2 (0.51) | JAK2TYK2JAK1JAK3MAPT | |
| SCHEMBL29552218 | 0.85 | JAK2 (0.43) | JAK2TYK2JAK1JAK3 | |
| SCHEMBL28362534 | 0.84 | JAK2 (0.51) | JAK2TYK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110818641-B | Pyridazine-3-formamide compound, preparation method and application thereof in medicine and pharmacology | 北京诺诚健华医药科技有限公司 | 2022-10-14 | — | — | CN | disclosed |