Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24916112 | 1.00 | EGLN1 (0.62) | EGLN1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL30054337 | 0.89 | EGLN1 (0.56) | EGLN1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL27167342 | 0.89 | EGLN1 (0.56) | EGLN1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL30054435 | 0.84 | EGLN1 (0.51) | EGLN1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL27167366 | 0.84 | EGLN1 (0.51) | EGLN1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL29923666 | 0.83 | EGLN1 (0.51) | EGLN1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL24916482 | 0.83 | EGLN1 (0.51) | EGLN1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL24886246 | 0.83 | WDR5 (0.49) | EGLN1KMT2A | |
| SCHEMBL12502967 | 0.82 | EGLN1 (0.83) | EGLN1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL24886114 | 0.82 | EGLN1 (0.46) | EGLN1ALDH1A1LMNASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4334305-A1 | WDR5 INHIBITORS AND MODULATORS | Vanderbilt University (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2022236101-A1 | WDR5 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY (US) | 2022-11-10 | — | — | WO | disclosed |
| EP-4055013-A1 | WDR5 INHIBITORS AND MODULATORS | Vanderbilt University (US) | 2022-09-14 | — | — | EP | disclosed |