Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 7/20 | 0.50 |
| ▸ | CPB1 | P15086 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 3/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 3/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2992421 | 1.00 | CCR2 (0.50) | CCR2CPB1ALDH1A1GAADPP4 | |
| SCHEMBL2989535 | 1.00 | CCR2 (0.50) | CCR2CPB1ALDH1A1GAADPP4 | |
| SCHEMBL2989537 | 1.00 | CCR2 (0.50) | CCR2CPB1ALDH1A1GAADPP4 | |
| SCHEMBL2983339 | 0.92 | CCR2 (0.51) | CCR2CPB1ALDH1A1GAADPP4 | |
| SCHEMBL2983334 | 0.92 | CCR2 (0.51) | CCR2CPB1ALDH1A1GAADPP4 | |
| SCHEMBL3091482 | 0.89 | CCR2 (0.48) | CCR2CPB1ALDH1A1GAADPP4 | |
| SCHEMBL3091490 | 0.89 | CCR2 (0.48) | CCR2CPB1ALDH1A1GAADPP4 | |
| SCHEMBL3091477 | 0.89 | CCR2 (0.48) | CCR2CPB1ALDH1A1GAADPP4 | |
| SCHEMBL3424924 | 0.89 | CCR2 (0.48) | CCR2CPB1ALDH1A1GAADPP4 | |
| SCHEMBL3424923 | 0.89 | CCR2 (0.48) | CCR2CPB1ALDH1A1GAADPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776884-B2 | Cyclic derivatives as modulators of chemokine receptors activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-08-17 | — | — | US | disclosed |
| US-7087604-B2 | Cyclic derivatives as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-08-08 | — | — | US | disclosed |