Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 12/20 | 0.46 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18729371 | 1.00 | CD274 (0.46) | CD274PDCD1MRGPRX4ALDH1A1MAPT | |
| SCHEMBL19897793 | 0.88 | CD274 (0.47) | CD274PDCD1MRGPRX4ALDH1A1MAPT | |
| SCHEMBL30395624 | 0.88 | CD274 (0.47) | CD274PDCD1MRGPRX4ALDH1A1MAPT | |
| SCHEMBL23078333 | 0.88 | MRGPRX4 (0.39) | CD274PDCD1MRGPRX4ALDH1A1MAPT | |
| SCHEMBL19897846 | 0.88 | CD274 (0.54) | CD274PDCD1MRGPRX4 | |
| SCHEMBL29925177 | 0.88 | MRGPRX4 (0.39) | CD274PDCD1MRGPRX4ALDH1A1MAPT | |
| SCHEMBL18729134 | 0.86 | MRGPRX4 (0.46) | CD274PDCD1MRGPRX4ALDH1A1MAPT | |
| SCHEMBL20540267 | 0.86 | ALDH1A1 (0.38) | CD274PDCD1MRGPRX4ALDH1A1MAPT | |
| SCHEMBL20540140 | 0.86 | CD274 (0.50) | CD274PDCD1MRGPRX4ALDH1A1MAPT | |
| SCHEMBL29724501 | 0.86 | ALDH1A1 (0.38) | CD274PDCD1MRGPRX4ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113365995-B | Immunomodulators, compositions and methods thereof | 贝达药业股份有限公司 | 2025-03-04 | — | — | CN | disclosed |
| CN-118878461-A | PD-1/PD-L1 inhibitors | 吉利德科学公司 | 2024-11-01 | — | — | CN | disclosed |
| CN-110582493-B | Benzoxazole derivatives as immunomodulators | 因赛特公司 | 2024-03-08 | — | — | CN | disclosed |
| CN-117561246-A | Novel biphenyl derivative, preparation method and medical application thereof | 西安新通药物研究股份有限公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-113307779-B | Heterocyclic substituted biphenyl compound, preparation method and application | 中国药科大学 | 2023-04-21 | — | — | CN | disclosed |
| CN-110267953-B | Tetrahydroimidazo [4,5-C ] pyridine derivatives as inducers of PD-L1 internalization | 因赛特公司 | 2022-12-20 | — | — | CN | disclosed |
| CN-113461668-B | Novel biphenyl derivative, preparation method and medical application thereof | 西安新通药物研究股份有限公司 | 2022-12-09 | — | — | CN | disclosed |
| WO-2022228286-A1 | NOVEL BIPHENYL DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICINAL USE THEREOF | 西安新通药物研究股份有限公司 | 2022-11-03 | — | — | WO | disclosed |