Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27032217 | 1.00 | KRAS (0.34) | KRASRXRARXRBRXRG | |
| SCHEMBL29925435 | 0.91 | RXRA (0.31) | KRASRXRARXRBRXRG | |
| SCHEMBL27032602 | 0.91 | RXRA (0.31) | KRASRXRARXRBRXRG | |
| SCHEMBL27128884 | 0.91 | RXRA (0.31) | KRASRXRARXRBRXRG | |
| SCHEMBL27032535 | 0.91 | RXRA (0.35) | RXRARXRBRXRG | |
| SCHEMBL29925779 | 0.91 | RXRA (0.35) | RXRARXRBRXRG | |
| SCHEMBL29925772 | 0.91 | RXRA (0.35) | RXRARXRBRXRG | |
| SCHEMBL29926053 | 0.89 | RXRA (0.34) | RXRARXRBRXRG | |
| SCHEMBL29925882 | 0.88 | RXRA (0.35) | RXRARXRBRXRG | |
| SCHEMBL27032237 | 0.88 | RXRA (0.35) | RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308570-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | Les Laboratoires Servier (FR) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022194976-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2022-09-22 | — | — | WO | disclosed |