Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 16/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | LSS | P48449 | 2/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27032307 | 1.00 | ATR (0.34) | ATRCNR2LSSKITFLT3 | |
| SCHEMBL27032614 | 0.91 | KIT (0.43) | ATRKITFLT3 | |
| SCHEMBL29925939 | 0.91 | KIT (0.43) | ATRKITFLT3 | |
| SCHEMBL29925929 | 0.79 | CYP4F2 (0.39) | CNR2FLT3 | |
| SCHEMBL27032089 | 0.79 | CYP4F2 (0.39) | CNR2FLT3 | |
| SCHEMBL27032444 | 0.78 | SIRT2 (0.44) | ATR | |
| SCHEMBL29925612 | 0.78 | SIRT2 (0.44) | ATR | |
| SCHEMBL27031993 | 0.75 | CYP4F2 (0.39) | ATR | |
| SCHEMBL29926016 | 0.75 | CYP4F2 (0.39) | ATR | |
| SCHEMBL29925610 | 0.75 | ATR (0.43) | ATRCNR2KITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308570-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | Les Laboratoires Servier (FR) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022194976-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2022-09-22 | — | — | WO | disclosed |