Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 9/20 | 0.43 |
| ▸ | FLT3 | P36888 | 5/20 | 0.43 |
| ▸ | ATR | Q13535 | 3/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27032614 | 1.00 | KIT (0.43) | KITFLT3ATRGPR84CNR1 | |
| SCHEMBL27032307 | 0.91 | ATR (0.34) | KITFLT3ATR | |
| SCHEMBL29925930 | 0.91 | ATR (0.34) | KITFLT3ATR | |
| SCHEMBL27032051 | 0.80 | CYP4F2 (0.42) | KITFLT3ATRGPR84REN | |
| SCHEMBL27032478 | 0.76 | CYP4F2 (0.39) | ATRCNR1 | |
| SCHEMBL29925579 | 0.76 | CYP4F2 (0.39) | ATRCNR1 | |
| SCHEMBL29925612 | 0.75 | SIRT2 (0.44) | ATR | |
| SCHEMBL27032444 | 0.75 | SIRT2 (0.44) | ATR | |
| SCHEMBL29925929 | 0.75 | CYP4F2 (0.39) | FLT3 | |
| SCHEMBL27032089 | 0.75 | CYP4F2 (0.39) | FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308570-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | Les Laboratoires Servier (FR) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022194976-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2022-09-22 | — | — | WO | disclosed |