Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.57 |
| ▸ | IKZF3 | Q9UKT9 | 10/20 | 0.56 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.56 |
| ▸ | HPGDS | O60760 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29132159 | 1.00 | CRBN (0.57) | CRBNIKZF3DDB1HPGDS | |
| SCHEMBL29927342 | 0.91 | CRBN (0.55) | CRBNIKZF3DDB1HPGDS | |
| SCHEMBL31043971 | 0.90 | CRBN (0.56) | CRBNDDB1HPGDS | |
| SCHEMBL29547197 | 0.88 | CRBN (0.54) | CRBNIKZF3DDB1HPGDS | |
| SCHEMBL22291366 | 0.88 | CRBN (0.54) | CRBNIKZF3DDB1HPGDS | |
| SCHEMBL27098632 | 0.88 | CRBN (0.54) | CRBNIKZF3DDB1HPGDS | |
| SCHEMBL31043982 | 0.88 | CRBN (0.58) | CRBNDDB1HPGDS | |
| SCHEMBL30938873 | 0.88 | CRBN (0.55) | CRBNIKZF3DDB1HPGDS | |
| SCHEMBL30683384 | 0.85 | CRBN (0.56) | CRBNIKZF3DDB1HPGDS | |
| SCHEMBL30683380 | 0.85 | CRBN (0.56) | CRBNIKZF3DDB1HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308557-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022198112-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |