Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.54 |
| ▸ | AR | P10275 | 4/20 | 0.54 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.47 |
| ▸ | BTK | Q06187 | 3/20 | 0.45 |
| ▸ | RAF1 | P04049 | 2/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 2/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29132051 | 1.00 | CRBN (0.54) | CRBNARDDB1BTKRAF1 | |
| SCHEMBL29927878 | 0.94 | CRBN (0.56) | CRBNARDDB1BTKRAF1 | |
| SCHEMBL29132293 | 0.94 | CRBN (0.56) | CRBNARDDB1BTKRAF1 | |
| SCHEMBL29927733 | 0.91 | CRBN (0.59) | CRBNARDDB1BTKRAF1 | |
| SCHEMBL29132140 | 0.91 | CRBN (0.59) | CRBNARDDB1BTKRAF1 | |
| SCHEMBL23249883 | 0.91 | CRBN (0.62) | CRBNARDDB1HPGDS | |
| SCHEMBL29132119 | 0.91 | CRBN (0.55) | CRBNARDDB1BTKRAF1 | |
| SCHEMBL29578907 | 0.90 | CRBN (0.58) | CRBNARDDB1BTKRAF1 | |
| SCHEMBL29927426 | 0.90 | CRBN (0.58) | CRBNARDDB1BTKRAF1 | |
| SCHEMBL29132100 | 0.90 | CRBN (0.58) | CRBNARDDB1BTKRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308557-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022198112-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |