SCHEMBL29928840

SCHEMBL29928840

CNC1CCN(c2ccc(Oc3cc(CNCCOC)cc(-c4cc(Cl)cc(Cl)c4)c3)cn2)CC1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ FURIN P09958 6/20 0.43
▸ STK4 Q13043 1/20 0.34
▸ STK3 Q13188 1/20 0.34
▸ LRRK2 Q5S007 1/20 0.34
▸ P4HTM Q9NXG6 1/20 0.33
▸ CHRM4 P08173 1/20 0.33
▸ SMO Q99835 2/20 0.33
▸ NPC1 O15118 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ TSHR P16473 1/20 0.33
▸ RAB9A P51151 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ MCHR1 Q99705 2/20 0.33
▸ RET P07949 1/20 0.33
▸ TLR7 Q9NYK1 1/20 0.33
▸ KCNH2 Q12809 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21551141 1.00 FURIN (0.43) FURINSTK4STK3LRRK2P4HTM
SCHEMBL21550748 0.79 FURIN (0.39) FURINMCHR1RETKCNH2
SCHEMBL29928103 0.79 FURIN (0.39) FURINMCHR1RETKCNH2
SCHEMBL21551365 0.76 FURIN (0.41) FURINNPC1RAB9A
SCHEMBL29928375 0.76 FURIN (0.41) FURINNPC1RAB9A
SCHEMBL26077362 0.76 FURIN (0.44) FURINCHRM4NPC1ALDH1A1LMNA
SCHEMBL21553814 0.76 NTRK1 (0.38) FURINCHRM4RET
SCHEMBL29928441 0.76 NTRK1 (0.38) FURINCHRM4RET
SCHEMBL26077363 0.75 FURIN (0.40) FURINNPC1ALDH1A1LMNAMAPT
SCHEMBL21550802 0.73 ZAP70 (0.38) FURINRET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4058021-A1 SMALL MOLECULE FURIN INHIBITORS FOR TREATING INFECTIOUS DISEASES BP Asset V, Inc. (US) 2022-09-21 — — EP claimed
US-20230011571-A1 SMALL MOLECULE FURIN INHIBITORS FOR TREATING INFECTIOUS DISEASES BP ASSET V, INC. (US) 2023-01-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230011571-A1 SMALL MOLECULE FURIN INHIBITORS FOR TREATING INFECTIOUS DISEASES FURIN, LGMN, PLAU FURIN 1/4885STK4 640/4885STK3 312/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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