Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B known ✓ | P49841 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.84 |
| ▸ | CA9 | Q16790 | 1/20 | 0.84 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.56 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.56 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 3/20 | 0.55 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.55 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | GRM5 | P41594 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | TDP2 | O95551 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | CASP9 | P55211 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.46 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL21081705 | 1.00 | CA12 (0.84) | CA12CA9CLK4DYRK1BNTRK2 | |
| SCHEMBL14896 | 0.92 | CA12 (1.00) | CA12CA9CLK4DYRK1BNTRK2 | |
| SCHEMBL4818277 | 0.92 | CA12 (1.00) | CA12CA9CLK4DYRK1BNTRK2 | |
| SCHEMBL29355184 | 0.92 | CA12 (1.00) | CA12CA9CLK4DYRK1BNTRK2 | |
| SCHEMBL11354047 | 0.90 | CA12 (0.95) | CA12CA9CLK4DYRK1BNTRK2 | |
| SCHEMBL8213864 | 0.90 | CA12 (0.95) | CA12CA9CLK4DYRK1BNTRK2 | |
| SCHEMBL8213866 | 0.90 | CA12 (0.95) | CA12CA9CLK4DYRK1BNTRK2 | |
| Water SCHEMBL19462706 | 0.90 | CA12 (0.95) | CA12CA9CLK4DYRK1BNTRK2 | |
| Hydrochloric Acid SCHEMBL5046932 | 0.90 | CA12 (0.95) | CA12CA9CLK4DYRK1BNTRK2 | |
| Water SCHEMBL19462703 | 0.90 | CA12 (0.95) | CA12CA9CLK4DYRK1BNTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115190895-A | High heat polycarbonate copolymer formulations | 高新特殊工程塑料全球技术有限公司 | 2022-10-14 | — | — | CN | disclosed |