Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 20/20 | 0.63 |
| ▸ | TLR8 | Q9NR97 | 20/20 | 0.63 |
| ▸ | TLR7 | Q9NYK1 | 20/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22463246 | 1.00 | TLR9 (0.63) | TLR9TLR8TLR7 | |
| SCHEMBL22463621 | 0.86 | TLR8 (0.58) | TLR9TLR8TLR7 | |
| SCHEMBL29928582 | 0.83 | TLR8 (0.65) | TLR9TLR8TLR7 | |
| SCHEMBL22463265 | 0.83 | TLR8 (0.65) | TLR9TLR8TLR7 | |
| SCHEMBL22463185 | 0.80 | TLR8 (0.59) | TLR9TLR8TLR7 | |
| SCHEMBL29928969 | 0.80 | TLR8 (0.59) | TLR9TLR8TLR7 | |
| SCHEMBL29928972 | 0.78 | TLR9 (0.64) | TLR9TLR8TLR7 | |
| SCHEMBL22463619 | 0.78 | TLR9 (0.64) | TLR9TLR8TLR7 | |
| SCHEMBL22554574 | 0.77 | TLR9 (1.00) | TLR9TLR8TLR7 | |
| SCHEMBL29626555 | 0.77 | TLR9 (1.00) | TLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111491930-B | Substituted Indole Compounds Useful as TLR Inhibitors | 百时美施贵宝公司 | 2023-09-26 | — | — | CN | claimed |
| EP-3728225-B1 | SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2022-11-09 | — | — | EP | claimed |
| CN-111491930-B | Substituted Indole Compounds Useful as TLR Inhibitors | 百时美施贵宝公司 | 2023-09-26 | — | — | CN | disclosed |