Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.41 |
| ▸ | CDK9 | P50750 | 3/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 3/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 2/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.33 |
| ▸ | CDK7 | P50613 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26977050 | 0.81 | SYK (0.49) | CDK2JAK2JAK1TYK2MEN1 | |
| SCHEMBL29929725 | 0.81 | CCNT1 (0.41) | CDK2CCNT1CCNE1CDK9CCNE2 | |
| SCHEMBL26980190 | 0.81 | CCNT1 (0.41) | CDK2CCNT1CCNE1CDK9CCNE2 | |
| SCHEMBL26980444 | 0.81 | CCNT1 (0.41) | CDK2CCNT1CCNE1CDK9CCNE2 | |
| SCHEMBL29929752 | 0.81 | CCNT1 (0.41) | CDK2CCNT1CCNE1CDK9CCNE2 | |
| SCHEMBL26977217 | 0.80 | JAK1 (0.43) | CDK2CCNT1CCNE1CDK9CCNE2 | |
| SCHEMBL27241016 | 0.80 | CCNT1 (0.39) | CDK2CCNT1CCNE1CDK9CCNE2 | |
| SCHEMBL26977291 | 0.80 | CCNT1 (0.39) | CDK2CCNT1CCNE1CDK9CCNE2 | |
| SCHEMBL29113552 | 0.78 | — | — | |
| SCHEMBL29929291 | 0.78 | MAPT (0.41) | MEN1KMT2AMAPTS1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4297873-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | Tyra Biosciences, Inc. (US) | 2024-01-03 | — | — | EP | disclosed |
| WO-2022182972-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | TYRA BIOSCIENCES, INC. (US) | 2022-09-01 | — | — | WO | disclosed |