Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | F2R | P25116 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26977540 | 1.00 | MAPT (0.41) | MAPTRPS6KA5KMT2AOPRK1ALDH1A1 | |
| SCHEMBL23611886 | 0.90 | MAPT (0.43) | MAPTRPS6KA5KMT2AOPRK1ALDH1A1 | |
| SCHEMBL30053407 | 0.90 | MAPT (0.43) | MAPTRPS6KA5KMT2AOPRK1ALDH1A1 | |
| SCHEMBL23611969 | 0.89 | MAPT (0.42) | MAPTRPS6KA5KMT2AOPRK1ALDH1A1 | |
| SCHEMBL29929645 | 0.89 | MAPT (0.42) | MAPTRPS6KA5KMT2AOPRK1ALDH1A1 | |
| SCHEMBL29929049 | 0.84 | VCAM1 (0.41) | MAPTKMT2AOPRK1ALDH1A1L3MBTL1 | |
| SCHEMBL26977398 | 0.84 | VCAM1 (0.41) | MAPTKMT2AOPRK1ALDH1A1L3MBTL1 | |
| SCHEMBL29929752 | 0.80 | CCNT1 (0.41) | MAPTALDH1A1 | |
| SCHEMBL26980190 | 0.80 | CCNT1 (0.41) | MAPTALDH1A1 | |
| SCHEMBL30671846 | 0.79 | CDC7 (0.44) | MAPTRPS6KA5KMT2AOPRK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4297873-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | Tyra Biosciences, Inc. (US) | 2024-01-03 | — | — | EP | disclosed |
| CN-117136184-A | Aminopyrimidine compounds and methods of use thereof | 泰拉生物科学公司 | 2023-11-28 | — | — | CN | disclosed |
| WO-2022182972-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | TYRA BIOSCIENCES, INC. (US) | 2022-09-01 | — | — | WO | disclosed |