Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 4/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 5/20 | 0.36 |
| ▸ | JAK2 | O60674 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26980380 | 1.00 | LRRK2 (0.44) | LRRK2CYP1A2PTK6SYKKDR | |
| SCHEMBL26980293 | 0.85 | LRRK2 (0.42) | LRRK2CYP1A2SYKKDRMAP4K1 | |
| SCHEMBL29929030 | 0.85 | LRRK2 (0.42) | LRRK2CYP1A2SYKKDRMAP4K1 | |
| SCHEMBL26980190 | 0.84 | CCNT1 (0.41) | LRRK2CYP1A2SYKKDRJAK1 | |
| SCHEMBL29929752 | 0.84 | CCNT1 (0.41) | LRRK2CYP1A2SYKKDRJAK1 | |
| SCHEMBL29113535 | 0.83 | LRRK2 (0.40) | LRRK2CYP1A2PTK6SYKKDR | |
| SCHEMBL29113534 | 0.83 | LRRK2 (0.39) | LRRK2CYP1A2SYKKDRJAK1 | |
| SCHEMBL29929286 | 0.81 | JAK3 (0.52) | — | |
| SCHEMBL26979886 | 0.81 | JAK3 (0.52) | — | |
| SCHEMBL26980492 | 0.75 | SYK (0.56) | SYKJAK1JAK2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4297873-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | Tyra Biosciences, Inc. (US) | 2024-01-03 | — | — | EP | disclosed |
| WO-2022182972-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | TYRA BIOSCIENCES, INC. (US) | 2022-09-01 | — | — | WO | disclosed |