Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.78 |
| ▸ | HPGD | P15428 | 8/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.78 |
| ▸ | NPC1 | O15118 | 3/20 | 0.78 |
| ▸ | RAB9A | P51151 | 3/20 | 0.78 |
| ▸ | CASP1 | P29466 | 4/20 | 0.62 |
| ▸ | CASP7 | P55210 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19436740 | 1.00 | KDM4E (0.78) | KDM4EHSD17B10HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL19436789 | 0.88 | ALDH1A1 (1.00) | KDM4EHSD17B10HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL14014110 | 0.88 | KDM4E (1.00) | KDM4EHSD17B10HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL19436766 | 0.87 | KDM4E (0.78) | KDM4EHSD17B10HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL19436759 | 0.87 | KDM4E (0.78) | KDM4EHSD17B10HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL29929922 | 0.87 | KDM4E (0.78) | KDM4EHSD17B10HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL29929991 | 0.87 | KDM4E (0.78) | KDM4EHSD17B10HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL29929061 | 0.87 | KDM4E (0.60) | KDM4EHSD17B10HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL19436708 | 0.87 | KDM4E (0.60) | KDM4EHSD17B10HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL19436682 | 0.87 | KDM4E (0.60) | KDM4EHSD17B10HPGDALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109311887-B | Pyrazolo [1,5-a ] pyrimidinecarboxamide compounds and their use in the treatment of medical conditions | BIAL研发投资股份有限公司 | 2022-09-13 | — | — | CN | disclosed |