⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23023244 | 1.00 | — | — | |
| SCHEMBL9538730 | 0.67 | — | — | |
| SCHEMBL15088134 | 0.67 | GRIN2D (0.33) | — | |
| SCHEMBL29909946 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL28956073 | 0.65 | — | — | |
| SCHEMBL5799303 | 0.65 | — | — | |
| SCHEMBL29362249 | 0.65 | — | — | |
| SCHEMBL12560643 | 0.61 | — | — | |
| SCHEMBL28307235 | 0.61 | — | — | |
| SCHEMBL28307325 | 0.60 | CHRNA7 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4540254-A1 | TETRAHYDROPYRIDOPYRIMIDINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2025-04-23 | — | — | EP | disclosed |
| WO-2023244604-A1 | TETRAHYDROPYRIDOPYRIMIDINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-12-21 | — | — | WO | disclosed |
| WO-2022194192-A1 | HETEROAROMATIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-09-22 | — | — | WO | disclosed |