Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23611734 | 1.00 | ALDH1A1 (0.42) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL23623339 | 0.99 | ALDH1A1 (0.43) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL23623240 | 0.89 | KMT2A (0.45) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL23623631 | 0.89 | KMT2A (0.45) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL23623306 | 0.88 | KMT2A (0.46) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL23623596 | 0.87 | KDM4E (0.46) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL23623320 | 0.85 | KMT2A (0.40) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL23644949 | 0.83 | ALDH1A1 (0.40) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL23623337 | 0.83 | POLB (0.39) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL23623323 | 0.81 | HDAC3 (0.47) | ALDH1A1MAPTKDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4085056-A1 | POLYCYCLIC AMIDES AS UBE2K MODULATORS FOR TREATING CANCER | Berg LLC (US) | 2022-11-09 | — | — | EP | disclosed |
| CN-115210229-A | Polycyclic amides as UBE2K modulators for the treatment of cancer | 博格有限责任公司 | 2022-10-18 | — | — | CN | disclosed |